Publications
 

Early life diet conditions the molecular response to post-weaning protein restriction in the mouse.
Amy F. Danson, Sarah J. Marzi, Robert Lowe, Michelle L. Holland, Vardhman K. Rakyan. 
BMC Biology. 2018 May. 16:51
 

Aging-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species
Robert Lowe, Carl Barton, Christopher A. Jenkins, Christina Ernst, Oliver Forman, Denise S. Fernandez-Twinn, Christoph Bock, Stephen J Rossiter, Chris G Faulkes, Susan E Ozanne, Lutz Walter, Duncan T Odom, Cathryn Mellersh, Vardhman K. Rakyan. Genome Biology. 2018 January. 19:22.
 

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.
Paul DS, Teschendorff AE, Dang MA, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S, Fouts AR, Ramelius A, Burden F, Farrow S, Rowlston S, Rehnstrom K, Frontini M, Downes K, Busche S, Cheung WA, Ge B, Simon MM, Bujold D, Kwan T, Bourque G, Datta A, Lowy E, Clarke L, Flicek P, Libertini E, Heath S, Gut M, Gut IG, Ouwehand WH, Pastinen T, Soranzo N, Hofer SE, Karges B, Meissner T, Boehm BO, Cilio C, Elding Larsson H, Lernmark Å, Steck AK, Rakyan VK*, Beck S*, Leslie RD*. Nat Commun. 2016 Nov 29;7:13555.

Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice.
Holland ML, Lowe R, Caton PW, Gemma C, Carbajosa G, Danson AF, Carpenter AA, Loche E, Ozanne SE, Rakyan VK. Science. 2016 Jul 29;353(6298):495-8.

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans.
Beyan H, Down TA, Ramagopalan SV, Uvebrant K, Nilsson A, Holland ML, Gemma C, Giovannoni G, Boehm BO, Ebers GC, Lernmark Å, Cilio CM, Leslie RD, Rakyan VK. Genome Res. 2012 Nov;22(11):2138-45

Epigenome-wide association studies for common human diseases.
Rakyan VK, Down TA, Balding DJ, Beck S. Nat Rev Genet. 2011 Jul 12;12(8):529-41.

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains.
Rakyan VK, Down TA, Maslau S, Andrew T, Yang TP, Beyan H, Whittaker P, McCann OT, Finer S, Valdes AM, Leslie RD, Deloukas P, Spector TD. Genome Res. 2010 20(4):434-9.

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis.
Down TA*, Rakyan VK* (* joint first and corresponding authors), Turner DJ, Flicek P, Li H, Kulesha E, Gräf S, Johnson N, Herrero J, Tomazou EM, Thorne NP, Bäckdahl L, Herberth M, Howe KL, Jackson DK, Miretti MM, Marioni JC, Birney E, Hubbard TJ, Durbin R, Tavaré S, Beck S. Nat Biotechnol. 2008 26(7):779-85.